国产精品自在在线香蕉-国产精品自在线拍国产-国产精品自在线拍-国产精品自在线-国产精品自在欧美一区-国产精品自线在线播放

最近搜索:細胞培養 微生物學 分子生物 生物化學
首頁>>免疫學>>一抗>>磷酸化胰島素受體底物1抗體
磷酸化胰島素受體底物1抗體
  • 產品貨號:
    BN40387R
  • 中文名稱:
    磷酸化胰島素受體底物1抗體
  • 英文名稱:
    Rabbit anti-phospho-IRS1 (Ser616) Polyclonal antibody
  • 品牌:
    Biorigin
  • 貨號

    產品規格

    售價

    備注

  • BN40387R-100ul

    100ul

    ¥2470.00

    交叉反應:Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用:WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產品描述

英文名稱phospho-IRS1 (Ser616)
中文名稱磷酸化胰島素受體底物1抗體
別    名IRS1 (phospho S616); p-IRS1 (phospho S616); HIRS 1; HIRS1; Insulin Receptor Substrate 1; IRS 1; IRS-1; IRS1; IRS1_HUMAN; OTTHUMP00000164234  
產品類型磷酸化抗體 
研究領域細胞生物  免疫學  神經生物學  細胞凋亡  糖尿病  細胞類型標志物  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量131kDa
細胞定位細胞核 細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human IRS1 around the phosphorylation site of Ser616:PM(p-S)PG 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]

Function:
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

Subunit:
Interacts with UBTF and PIK3CA (By similarity). Interacts (via phosphorylated YXXM motifs) with PIK3R1 (By similarity). Interacts with ROCK1 and FER (By similarity). Interacts (via PH domain) with PHIP (By similarity). Interacts with GRB2 (By similarity). Interacts with SOCS7. Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif). Interacts with ALK. Interacts with EIF2AK2/PKR (By similarity).

Post-translational modifications:
Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor. Phosphorylation of Tyr-896 is required for GRB2-binding.

DISEASE:
Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].

Similarity:
Contains 1 IRS-type PTB domain.
Contains 1 PH domain.

SWISS:
P35568

Gene ID:
3667

Database links:

Entrez Gene: 3667 Human

Entrez Gene: 16367 Mouse

Entrez Gene: 25467 Rat

Omim: 147545 Human

SwissProt: P35568 Human

SwissProt: P35569 Mouse

SwissProt: P35570 Rat

Unigene: 471508 Human

Unigene: 4952 Mouse

Unigene: 10476 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


主站蜘蛛池模板: 孟村| 固原市| 章丘市| 老河口市| 乌兰察布市| 依兰县| 娱乐| 老河口市| 内乡县| 西昌市| 内乡县| 乐东| 繁昌县| 普兰县| 甘南县| 伽师县| 密云县| 晋城| 五大连池市| 昭苏县| 门源| 拉萨市| 团风县| 淮北市| 瓮安县| 临朐县| 昂仁县| 麻城市| 宁波市| 教育| 南靖县| 昭通市| 磴口县| 郧西县| 岫岩| 尉犁县| 通江县| 彭阳县| 咸宁市| 电白县| 永年县|